Sistema de Información de Ciencia y Tecnología

Enfermedades Diarreicas

Nombre Abreviado 385 DIARREICAS

Financiamiento ASDI

Convocatoria Programa UMSA - ASDI 2013 - 2017

Categoria y Convocatoria del proyecto Programa UMSA - ASDI

Duración Inicio: 01/06/2012 Fin: 01/06/2017

Tipo de Investigación Aplicada

Datos SIGEP:

Unidad ejecutora	Programa	Sub-programa	Proyecto	Actividad
95	51	0	0000	385

Resumen del Proyecto

Summary Acute Diarrheal Diseases (ADD) represents a major public health problem in developing countries. According to the World Health Organization (WHO 2008) each year there are around 2 billion diarrheal episodes that are responsible for the death of ca 2 million (1.7 - 2.5 million) children under 5 years of age, ranking second among all causes of infectious disease deaths worldwide (Walker et al., 2012). In Bolivia, where child mortality rate is one of the highest in Latin America and the Caribbean region, ADD account for the fourth highest percentage of deaths in the region (UNICEF, 2009). Conservative estimates, place the death toll from diarrheal diseases at 13,000 to 15,000 deaths per year, with most of these occurring in children less than 2 years of age. Moreover, enteric infections that occur during early childhood have lasting detrimental effects on later physical and cognitive development impairment of affected children (Guerrant et al., 2002). An inadequate water supply, improper sanitation, overcrowding, malnutrition and lack of primary health care, are the main factors...Ver mas

Summary Acute Diarrheal Diseases (ADD) represents a major public health problem in developing countries. According to the World Health Organization (WHO 2008) each year there are around 2 billion diarrheal episodes that are responsible for the death of ca 2 million (1.7 - 2.5 million) children under 5 years of age, ranking second among all causes of infectious disease deaths worldwide (Walker et al., 2012). In Bolivia, where child mortality rate is one of the highest in Latin America and the Caribbean region, ADD account for the fourth highest percentage of deaths in the region (UNICEF, 2009). Conservative estimates, place the death toll from diarrheal diseases at 13,000 to 15,000 deaths per year, with most of these occurring in children less than 2 years of age. Moreover, enteric infections that occur during early childhood have lasting detrimental effects on later physical and cognitive development impairment of affected children (Guerrant et al., 2002). An inadequate water supply, improper sanitation, overcrowding, malnutrition and lack of primary health care, are the main factors involved in the spread and severity of these diseases. The current situation will likely be exacerbated by climate change, as less access to clean water will likely increase the burden of diarrheal disease and malnutrition and its concomitant risk of death and disability in children.

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Impacto

Tesis de  PhD aprobada Lucia Gonzales. ETEC: Epidemiologia caracterización molecular. University of Goteborg, July, 2013

Tesis de  Maestria aprobada: Bladimir Colquillo: Norovirus.  Maestria de Ciencias Biologicas y Biomedicas,UMSA, Agosto, 2013

4 artículos publicados en revistas internacionales

1 presentación oral  en conferencia internacional

Se evaluó la distribución de   patógenos bacterianos (ETEC, EHEC, EAEC, EPEC) en muestras de aguas de la cuenca del Rio La Paz

Beneficiarios: niños hospitalizados con EDA

Objetivos

Objetivo General

• To improve in the next 5 years effectiveness of DD management and prevention in Bolivia.

Objetivos Especificos

• - To increase application of research in the field of DD.
  - To improve national policies for DD treatment, control and prevention by addressing DD etiology pathogenesis and antibiotic resistance of enteric microorganisms in clinical settings.
  - To improve policies for DD treatment, control and prevention by addressing DD etiology, pathogenesis and antibiotic resistance of enteric microorganisms in environmental settings.

Participantes

Coordinador Volga Iñiguez Rojas

Co-cordinador

- Participantes del proyecto

Nombre	Grado Académico	Cargo	Cédula de identidad
Erick Castillo Laura	Licenciatura	Apoyo administrativo (Categoria D)
Elmer Javier Pereyra Arias	Licenciatura	Becario PostGrado (Categoria D)
Carla Marcia Nogales Chuquimia	Licenciatura	Becario PostGrado (Categoria D)
Leonarda Acha Alarcon		Becario PostGrado (Categoria D)
Lucia Paola Inchauste Jordan	Bachiller	Becario Pregrado (Categoria D)
Volga Iñiguez Rojas	Doctorado Ph.D.	Coordinador (Categoria D)
Carol Jessica Guzman Otazo	Doctorado Ph.D.	Doctorando (Categoria D)
Nataniel Mamani Chura	Licenciatura	Investigador (Categoria D)
Elmer Javier Pereyra Arias	Licenciatura	Maestrante (Categoria D)
Sonia Guadalupe Jimenez Pacohuanca	Maestria	Maestrante (Categoria D)

- Colaboradores del proyecto

Nombre	Grado Académico	Cargo	Cédula de identidad
Ruben Choque Condori [email protected]		Chofer (Categoria D)
Hermenegildo Fernandez Callisaya	Bachiller	Chofer (Categoria D)
Esther Ninoska Flores Quisbert [email protected]	Doctorado Ph.D.	Coordinador de postgrado (Categoria D)
Asa Sjoling		Supervisor ()
Volga Iñiguez Rojas [email protected]	Doctorado Ph.D.	Supervisor ()
Volga Iñiguez Rojas [email protected]	Doctorado Ph.D.	Supervisor (Categoria D)

Unidades Participantes

Unidad Proponente Instituto de Biología Molecular y Biotecnología

Unidad Contraparte

+ Unidades Co-Ejecutoras

Nombre de la Unidad	Responsable de la Unidad

Lineas de Investigación

• Enteropatógenos

Publicaciones generadas por el proyecto

Shiga toxin-mediated disease in MyD88-deficient mice...



Studies of the pathogenesis of Enterohemorrhagic...

Cross-reactive protection against Enterohemorrhagic Escherichia coli...

Intestinal damage in Enterohemorrhagic Escherichia coli...